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Polarized Light in Biomedicine: General Principles and Specific Preclinical / Clinical Examples
Polarized light applications in biomedicine are challenged by the multiply-scattering heterogeneous nature of biological tissues. Yet polarimetry’s unique advantages, if realized, are numerous and include (1) rich information content based on endogenous tissue contrast, (2) ability to image large tissue regions (capturing the often-missed spatial heterogeneity of disease), (3) fast measurement times, (4) ability to examine any tissue state (in-vivo or ex-vivo, fresh or frozen, fixed or embedded), (5) robust low-noise measurement systems, and (6) relatively simple and affordable instrumentation. In this presentation, I will briefly discuss the various technological tradeoffs and solutions in polarimetric biomedicine, and illustrate with study examples of stromal (collagen) quantification in the tumour microenvironment.

Jun 28, 2022 02:00 PM in Pacific Time (US and Canada)

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Alex Vitkin
Prof. of Medical Biophysics and Radiation Oncology @University of Toronto (Canada)
Alex Vitkin is a professor of Medical Biophysics and Radiation Oncology at the University of Toronto, a senior scientist at the University Health Network, and a clinical medical physicist at Princess Margaret Cancer Centre (all in Toronto, Ontario, Canada). He has published over 180 papers and book chapters on biomedical optics (Google Scholar H-index = 57), specializing in tissue polarimetry and functional OCT. He has delivered special seminars and summer school modules on biophotonics in 26 countries, often through SPIE’s and Optica’s Visiting Lecturer programs. Dr. Vitkin is a Fellow of Optica, SPIE and AIMBE, and the 2022 recipient of the SPIE GG Stokes Award in optical polarization.